Publications

 Key Publications

  1. Savino AM, Fernandes SI, Olivares O, Zemlyansky A, Cousins A, Markert EK, Shani Barel S, Geron I, Frishman L, Birger Y, Eckert C, Tumanov S, MacKay G, Kamphorst JJ, Pawel Herzyk P, Fernández-García J, Abramovich I, Mor I, Bardini M, Barin E, Janaki-Raman S, Cross JR, Kharas MG, Gottlieb E*, Izraeli S*, Halsey C*. Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on Stearoyl CoA desaturase. Nature Cancer: 1-12, 2020 (*Corresponding authors) [Link]
  2. Lagziel S, Gottlieb E*, Shlomi T*. Mind your media. Nature Metab, 2020 (*Corresponding authors) [Link]
  3. Krauß D, Gottlieb E. Restraining colorectal cancer with αKG. Nature Cancer 1: 267-269, 2020 [Link]
  4. Ghrayeb A, Gottlieb E*, Mor I*. Alcohol-derived acetate modulates brain function. Nature Metab 1: 1036-1037, 2019 (*Corresponding authors) [Link]
  5. Vande Voorde J, Ackermann T, Pfetzer N, Sumpton D, Mackay G, Kalna G, Nixon C, Blyth K, Gottlieb E, Tardito S. Improving the metabolic fidelity of cancer models with a physiological cell culture medium. Sci Adv 5: 7314, 2019 [Link]
  6. van der Reest J, Lilla S, Zheng L, Zanivan S, Gottlieb E. Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress. Nature Commun 9: 1581, 2018 [Link]
  7. Kuntz EM, Baquero P, Michie AM, Dunn K, Tardito S, Holyoake TL, Helgason GV, Gottlieb E. Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells. Nature Med 23: 1234-1240, 2017 [Link]
  8. Bulusu V, Tumanov S, Michalopoulou E, van den Broek NJ, MacKay G, Nixon C, Dhayade S, Schug ZT, Vande Voorde J, Blyth K, Gottlieb E, Vazquez A, Kamphorst JJ. Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation. Cell Rep 18: 647-658, 2017 [Link]
  9. Schug ZT, Vande Voorde J, Gottlieb E. The Metabolic Fate of Acetate in Cancer. Nature Rev Cancer 16: 708-717, 2016. Review [Link]
  10. Tardito S, Oudin A, Ahmed SU, Fack F, Keunen O, Zheng L, Miletic H, Sakariassen PO, Weinstock A, Wagner A, Lindsay SL, Hock AK, Barnett SC, Ruppin E, Mørkve SH, Lund-Johansen M, Chalmers AJ, Bjerkvig R, Niclou SP, Gottlieb E. Glutamine Synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nature Cell Biol 17: 1556-1568, 2015 [Link]
  11. Cardaci S, Zheng L, MacKay G, van den Broek NJ, MacKenzie ED, Nixon C, Stevenson D, Tumanov S, Bulusu V, Kamphorst JJ, Vazquez A, Fleming S, Schiavi F, Kalna G, Blyth K, Strathdee D, Gottlieb E. Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis. Nature Cell Biol 17: 1317-1326, 2015 [Link]
  12. Zheng L, Cardaci S, Jerby L, MacKenzie ED, Sciacovelli M, Johnson TI, Gaude E, King A, Leach JDG, Edrada-Ebel R, Hedley A, Morrice NA, Kalna G, Blyth K, Ruppin E, Frezza C, Gottlieb E. Fumarate induces redox-dependent senescence by modifying glutathione metabolism. Nature Commun 6: 6001, 2015 [Link]
  13. Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K, McGarry L, James D, Shanks E, Kalna G, Saunders R, Jiang M, Howell M, Lassailly F, Thin MZ, Spencer-Dene B, Stamp G, van den Broek N, Mackay G, Bulusu V, Kamphorst JJ, Tardito S, Strachan D, Harris AL, Aboagye EO, Critchlow SE, Wakelam MJO, Schulze A, Gottlieb E. Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth Under Metabolic Stress. Cancer Cell 27: 57-71, 2015 [Link]
  14. Mackay GM, Zheng L, van den Broek NJ, Gottlieb E. Analysis of Cell Metabolism Using LC-MS and Isotope Tracers. Methods Enzymol 561: 171-196, 2015. Review [Link]
  15. Jerby-Arnon L, Pfetzer N, Waldman YY, McGarry L, James D, Shanks E, Seashore-Ludlow B, Weinstock A, Geiger T, Clemons PA, Gottlieb E, Ruppin E. Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality. Cell 158: 1199-1209, 2014 [Link]
  16. Maddocks ODK, Berkers C, Mason S, Zheng L, Blyth K, Gottlieb E, Vousden KH. Serine starvation induces stress and p53 dependent metabolic remodelling in cancer cells. Nature, 493: 542-546, 2013 [Link]
  17. Rosenfeldt MT, O’Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, Au A, Rai TS, Zheng L, Ridgway R, Adams P, Anderson KI, Gottlieb E, Sansom OJ, Ryan KM. p53 status determines the role of autophagy in pancreatic tumour development. Nature 505: 296-300, 2013 [Link]
  18. Zheng L, MacKenzie ED, Karim SA, Hedley A, Blyth K, Kalna G, Watson DG, Szlosarek P, Frezza C, Gottlieb E. Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells. Cancer Metab 1: 12, 2013 [Link]
  19. Durán RV, MacKenzie ED, Boulahbel H, Frezza C, Heiserich L, Tardito S, Bussolati O, Rocha S, Hall MN, Gottlieb E. HIF-independent role of Prolyl Hydroxylases in the cellular response to amino acids. Oncogene 32: 4549-4556, 2013 [Link]
  20. Kaplon J, Zheng L, Meissl K, Chaneton B, Selivanov VA, MacKay G, van der Burg SH, Verdegaal EME, Cascante M, Shlomi T, Gottlieb E*, Peeper DS*. A critical role for the mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. Nature 498: 109-112, 2013 (*Corresponding Author) [Link]
  21. Chaneton B, Gottlieb E. Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer. Trends Biochem Sci 37: 309-316, 2012. Review [Link]
  22. Durán RV, Oppliger W, Robitaille AM, Heiserich L, Gottlieb E, Hall MN. Glutaminolysis activates the Rag-mTORC1 signaling pathway. Mol Cell 47: 349-358, 2012 [Link]
  23. Chaneton B, Hillmann P, Zheng L, Martin ACL, Maddocks ODK, Chokkathukalam A, Coyle JE, Jankevics A, Holding FP, Vousden KH, Frezza C, O’Reilly M, Gottlieb E. Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature 491: 458-462, 2012 [Link]
  24. Frezza C, Zheng L, Folger O, Rajagopalan KN, MacKenzie ED, Jerby L, Micaroni M, Chaneton B, Adam J, Hedley A, Kalna G, Tomlinson IPM, Pollard PJ, Watson DG, Deberardinis RJ, Shlomi T, Ruppin E, Gottlieb E. Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase. Nature 477: 225-228, 2011 [Link]
  25. Tennant DA, Durán RV, Gottlieb E. Targeting metabolic transformation for cancer therapy. Nature Rev Cancer 10: 267-277, 2010. Review [Link]
  26. Tennant DA, Frezza C, MacKenzie ED, Nguyen Q-D, Zheng L, Selak MA, Roberts DL, Dive C, Watson DG, Aboagye EO, Gottlieb E. Re-activating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death. Oncogene 28: 4009-4021, 2009  [Link]
  27. Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nadano K, Bartrons R, Gottlieb E, Vousden, KH. TIGAR, a novel regulator of glycolysis  and apoptosis, is induced by p53. Cell 126: 107-120, 2006  [Link]
  28. Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD, Yi P, Simon MC, Thompson CB, Gottlieb E. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase. Cancer Cell 7: 77-85, 2005 [Link]
  29. Gottlieb E*, Tomlinson IPM. Mitochondrial tumour suppressors: a genetic and biochemical update. Nature Rev Cancer 5: 857-866, 2005 (*Corresponding Author) Review [Link]